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KMID : 0388019950060040227
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Korean Journal Gynecologic Oncology and Colposcopy
1995 Volume.6 No. 4 p.227 ~ p.234
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Significance of Insulin-Like Growth Factor-1(IGF-1) in the Ascites of the Ovaran Cancer
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나영정
김경태/유중배/문영진/문형/황윤영/신재훈
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Abstract
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OBJECTIVES :
@EB To evaluate the concentration of IGF-1 in the ascites of ovarian cancer patients and to analyze the patient's clinical and pathologic propnostic factors.
@ES STUDY METHODS :
@EN The present study measured the concentration of IGF-1 from 23 patients undergoing surgery for ovarian cancer at Hanyang University Hospital ascitic fluid could be obtained. IGF-1 was measured with radioisotopes. Ascites of nonmalignant origin
from
10 patients (liver cirrhosis or preeclampsia) were used as the control. The 23 patients underwent chemotherapy with cis-platinum following surgery.
@ES RESULTS :
@EN The average concentration of IGF-1 in the ascites of the patient group was 820.7ng/ml, a much higher level than the 394.8ng/ml of the control group(p=0.019). The concentration of the IGF-1 increased as the stage and size of the tumor
increased,
but
showed no correlation with other prognostic factors including patients age, tumor differentiation or histologic type, size of residual tumor, serum CA 125 levels or survival rate, The response rate to chemotherapy was greater in patients with
lower
concentrations of IGF-1.
@ES CONCLUSION :
@EN A large amount of IGF-1 exists in the ascites of patients with ovarian cancer, and that this level increases as the size or stage of the tumor increases but has no correlation with other prognostic factors or the survival rate. But we
emphasize
the
need for further studies including levels of IGFBP1-6 and other growth factors with a larger number patients.
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KEYWORD
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